Everything about Pyrazine totally explained
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Pyrazine is a
heterocyclic aromatic organic compound.
Pyrazine is a symmetrical molecule with
point group D2h. It is found in
folic acid in the form of
pterin.
Derivatives like
Phenazine are well known for their antitumor, antibiotic and diuretic activity.
Pyrazine is less basic in nature than pyridine, pyridazine and pyrimidine.
Tetramethylpyrazine is reported to scavenge superoxide anion and decrease nitric oxide production in human
polymorphonuclear leukocytes. It is also found on the
cigarette additives list.
Synthesis
Many methods exist for the
organic synthesis of pyrazine and derivatives and some of them very old.
In the
Staedel-Rugheimer pyrazine synthesis (1876)
2-chloroacetophenone is reacted with
ammonia to the amino ketone, then condensed and then oxidized to a pyrazine A variation is the
Gutknecht Pyrazine Synthesis (1879) also based on this
selfcondensation but differing in the way the alpha-ketoamine is synthesised (the chlorine compound in the above method is a
lachrymatory agent)
»
The
Gastaldi synthesis (1921) is another variation :
» Further Information
Get more info on 'Pyrazine'.
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